Emdotrim 60% MIX

Water-soluble powder for oral use

Composition

Trimethoprim 100 mg + Sulfadia¬zine sodium eq. Sulfadiazine 500 mg per gram of powder.

Pharmacotherapeutic category

Antibacterials for systemic use (Combination of sulfonamides and trimethoprim).

Properties

The mechanism of antimicrobial action of the combination consists of inhibition of two sequential steps in the synthesis of bacterial folic acid. The combination possesses a synergistic potential that may result in a substantial reduction of dose for both components.The combination is active against a wide range of Gram-positive and Gram-negative bacteria, such as Escherichia coli, Shigella spp., Klebsiella spp., Proteus vulgaris, Pasteurella spp., Staphylococcus spp., Streptococ¬cus spp., Pneumococcus spp., Salmonella spp., Actinomyces spp. and others.

Indications

For the treatment of infections caused by trimethoprim/sulfadiazine susceptible microorganisms.

Dosage, route and method of administration

Oral administration: 30 mg of trimethoprim /sulfadiazine combination per kg BW or 1 gram of Emdotrim 60% MIX powder per 20 kg BW per day, divided over two equal doses in the morning and evening for 5 days.

Shelf-life

3 years.

Packaging

Bags or boxes with 100, 500, 1000 or 2000 gram of powder.



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